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| Dosages: | | ORAL: ACUTE LYMPHOBLASTIC LEUKAEMIA: Maintenance phase 15mg/m2 once or twice weekly.
PSORIASIS: 10-25mg/day.
RHEUMATOID ARTHRITIS: 7.5mg weekly.
CHORIOCARCINOMA: 15-30mg/day for 5 days at intervals of 1-2 weeks for 3-5 cycles.
BURKITTS LYMPHOMA: 10-15mg/day for 4-8 days, repeated after 7-10 days.
MYCOSIS FUNGOIDES: 2.5-10mg/day to induce remission.
IM/IV: PSORIASIS: 10-25mg weekly. IM:ACUTE LYMPHOBLASTIC LEUKAEMIA: 15mg/m2 once or twice weekly. Alternatively 2.5mg/kg by IV every 14days.
IM: CHORIOCARCINOMA: 15-30mg/m2 for 5 days at intervals of 1-2 weeks. 3-5 such cycles.
IM: BURKITTS LYMPHOMA: 50mg as a single dose or in 2 divided doses weekly.
ADVANCED LYMPHOSARCOMA: 3-30mg/kg OR 90-900mg/m2 by IV with Folinic acid rescue.
MENINGEAL LEUKAEMIA: 12mg/m2 (not ot exceed 15mg) once or twice weekly Intrathecally. Alternatively 500mg/m2 by IV followed by Folinic acid rescue. |
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